It would be with an all original cast and town. No mutants, zombies or cannon characters.
From Wikipedia:
http://en.wikipedia.org/wiki/Jericho_(TV_series)
The storyline revolves about the residents of Jericho, a small, rural Kansas town, in the aftermath of nuclear attacks on twenty-three major cities in the contiguous United States. The series begins with a visible nuclear detonation of unknown origin over nearby Denver, Colorado, and a loss of power and modern communications, effectively isolating Jericho
